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Development and plasticity of the postnatal brain

A principal goal in brain development is to produce the necessary neural architecture for integration of information from the external environment with internal cues that reflect important aspects of an individual's physiological state. This integration allows the elaboration of adaptive behavioral and physiological responses that are essential for an individual's survival, as well as for propagation of the species. It is well established that many circulating hormones represent important environmental signals that act directly on the central nervous system (CNS) to regulate its development and activity. Our laboratory studies how peripheral hormones (estrogen, AMH, leptin, ghreline, insulin,...) impact hypothalamic development and function as well as in determining the importance of non-neuronal cells (tanycytes, astrocytes and endothelial cells) in this dialogue, which is set between the periphery and the central nervous system. It will also evaluate how pathologies (such as obesity, diabetes) may affect these neurobiological events and, conversely, how impairment of brain communication with the periphery renders the organism prone to develop pathologies (obesity, diabetes, precocious and/or delayed puberty and infertility) that are sometimes associated with cognitive deficits in patients.

 

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Figure

ARH/me: arcuate nucleus of the hypothalamus/median eminence; GnRH: gonadotropin releasing hormone; POA: preoptic region; PVH: Periventricular nucleus of the hypothalamus; DMH: dorsomedian nucleus of the hypothalamus; LHA: lateral hypothalamic area.

Références

Baroncini M, Jissendi P, Catteau-Jonard S, Dewailly D, Pruvo JP, Francke JP, Prevot V (2010) Sex steroid hormones-related structural plasticity in the human hypothalamus. Neuroimage 50:428-433.

Baroncini M, Jissendi P, Balland E, Besson P, Pruvo JP, Francke JP, Dewailly D, Blond S, Prevot V (2012) MRI atlas of the human hypothalamus. Neuroimage 59:168-180.

 

Laboratory's name
NEUROBESE International Associated Laboratory (Inserm, Children Hospital of Los Angeles, Univ Lille 2)
Head of the lab
Vincent Prevot
Contact DN2M
Vincent Prevot
Email
vincent.prevot(at)inserm.fr
Telephone
+33 3 20 29 88 53
Address
Inserm U837, Bâtiment Biserte, place de Verdun, 59045 Lille Cedex
Website
http://www.crjpa.lille.inserm.fr/axe-neurosciences/equipe-2