DN2M » Network » Alzheimer & Tauopathies

Alzheimer & Tauopathies

“Alzheimer & Tauopathies” team belongs to the “Jean-Pierre Aubert Research Centre” that is composed of 6 research teams (200 individuals) dedicated to Cancer and Neuroscience investigations. Our team is composed of 15 permanent researchers: full time research scientists, professors and associate professors and clinicians. We also welcome postdoctoral fellows and MSc/PhD students. Our work focuses on the physiopathology of Alzheimer’s disease and related disorders referred to as Tauopathies going from the gene to the clinic and from basic research to biomedical application. “Alzheimer & Tauopathies” team is interested in molecular and pathophysiological mechanisms. Our main contribution has been on the characterization of neuro-degenerative disorders with dysfunction in tau metabolism (expression, splicing, etc…) and the development of experimental models. We also demonstrated that Tau proteins are biomarkers of these disorders and correlated to neuronal death.

Our current research should lead to new diagnostic and therapeutic strategies of Alzheimer’s disease and related disorders. To the level of the etiopathogenesis of Alzheimer’s disease, the understanding of the relationships between amyloid pathology and tau pathology is our main goal. Any molecular actors potentially involved in one of these pathways are evaluated in our experimental “humanized” models, as well as the related pharmacological aspects.

 

Laboratory's name
Alzheimer & Tauopathies
Head of the lab
Luc Buée
Contact DN2M
Luc Buée
Email
luc.buee(at)inserm.fr
Telephone
+33 3 20 29 88 50
Address
Inserm U837 Equipe 1, Bâtiment Biserte, place de Verdun, 59045 Lille Cedex
Website
http://www.crjpa.lille.inserm.fr/axe-neurosciences/equipe-1