DN2M » Pathophysiological mechanisms

Pathophysiological mechanisms

Whereas in Alzheimer’s disease, two brain lesions are known: amyloid deposits which result from the accumulation of Aß peptides and neurofibrillary tangles which are formed with the aggregation of the microtubule-associated Tau protein into filaments. In other Tauopathies, only Tau aggregation is observed and also leads to neuronal cell death. Which mechanisms underlie Tau aggregation and how it is related to the amyloid pathology in AD? These main fundamental questions may lead to a translational research with the identification of either risk or protective factors. Moreover, the identification of the key actors involved in the pathophysiological mechanisms are also helpful for improving diagnosis on the identification of biomarkers (genetics, proteomics, imaging) and allowing for the development of innovative therapeutic strategies. DN2M is, in this respect, a wonderful network to facilitate links and exchanges between fundamental research and clinics.